stepkerop.blogg.se

High programmer il
High programmer il






high programmer il

The effectiveness of these cells in vivo is determined by a number of parameters including quantity, array of cytokines produced, lytic activity, and peptide sensitivity. Finally, these studies uncover an unexpected role for oxidative phosphorylation in regulating differentiation in these cells.ĬD8 + T cells are a critical component of the adaptive immune system's ability to clear virus and tumor cells. Further, they reveal a new pathway for the self-tuning of peptide sensitivity. Together these data demonstrate a novel mechanism for the regulation of IL-4 production in CD8 + T cells. IL-4 signaling in the activated OT-I CD8 + T cell results in modulation of the sensitivity of the cell, establishing a higher activation setpoint that is maintained over time. Both metabolic pathways are required for this cytokine to be made. Our data suggest this altered metabolic program results in the production of autocrine IL-4. This diverges from the switch to a predominantly glycolytic profile that would be predicted following naïve T cell activation.

high programmer il

We find that in the presence of a strong TCR engagement event there is a shift in the metabolic programming of the cell where both glycolysis and oxidative phosphorylation are significantly increased. Here we report a new pathway through which TCR transgenic OT-I CD8 + T cells can self-tune their activation threshold. One of the important properties that contributes to this goal is the activation set-point of the T cell. The ability of T cells to sense and respond to environmental cues by altering their functional capabilities is critical for a safe and optimally protective immune response. 3Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, United States.

high programmer il

  • 2Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • 1Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, United States.







  • High programmer il